A new research paper published by the the journal Clinical and Experimental Allergy, shows that after inhaling spores from the mold Aspergillus fumigatus, the lungs of mice developed significant adverse changes, linked with both allergic and inflammatory processes. The researchers stated that treatment of a mold illness should consider both allergy and inflammation.

The study concluded,”Repeated inhalation of fungal aerosols resulted in significant pulmonary pathology mediated by dynamic shifts in specific immune populations and their cytokines. These studies provide novel insights into the immunological mechanisms and targets that govern the health outcomes that result from repeated inhalation of fungal bioaerosols in contaminated environments.”

This research is GREAT NEWS for people who are suffering from various mold illnesses that both allergies and inflammation are being recognized more and more by the scientific community as symptoms of mold exposure. These scientific revelations will help educate main stream medical practitioners who have been mostly ignorant to these facts and often label people who say they are sick from mold as either lying and/or crazy.

According to the American College of Allergy, Asthma & Immunology: “If you have an allergy that occurs over several seasons, you may be allergic to the spores of molds or other fungi. Molds live everywhere. Upsetting a mold source can send the spores into the air.”

Dori Germolec, Ph.D., leader of the NTP Systems Toxicology Group had said this about this about the study, “Until now, there has been very limited evidence that germination is necessary for these responses. The project was conducted in collaboration with Ajay Nayak, Ph.D. and Brett Green, Ph.D., of the NIOSH Health Effects Laboratory Division (HELD), and Donald Beezhold, Ph.D., HELD director.

“We need to consider germination as an important component of potential toxicity when studying fungi,” Germolec stressed. “However, while we have found germination necessary for Aspergillus, it may not be necessary for all fungi,” she said. “Some, for example, have much larger conidia, which may not even get into the lung.” Conidia are fungal spores involved in reproduction.

The findings have important implications for treatment of individuals living or working in moldy environments. “We now understand more about the kind of disease that can develop,” Germolec said. “The findings suggest that treatment should not target inflammation or allergy alone, but should consider both.”

Researchers found that animals that experienced subchronic exposure, which lasted 13 weeks, showed changes in the lungs consistent with the development of allergic responses, although the mice were not previously allergic. Cells in the lungs and airways experienced chronic inflammation and expressed a cytokine called interleukin-13, which is a hallmark of allergic response and plays a key role in allergic inflammation and airway diseases.

“This is a critical finding, as it demonstrates that a significant fraction of the T cells [immune response cells] that drive anti-fungal responses also contribute to the allergic outcomes,” the authors wrote.

“These results provide valuable insights for treatment of individuals exposed to moldy environments, whether a school, business, or home,” said Stavros Garantziotis, M.D., lead researcher for the NIEHS Natural History of Asthma with Longitudinal Environmental Sampling, or NHALES, study. He was not involved in the present research.

This research is in line with my previous article titled, “Is mold the cause of your allergies and/or asthma?,” where I detailed research showing that Aspergillus causes a groups of diseases called Aspergillosis. The most common subtype among paranasal sinus infections associated with aspergillosis is A. fumigatus. The symptoms include fever, cough, chest pain, or breathlessness, which also occur in many other illnesses, so diagnosis can be difficult.


  1. Nayak AP, Green BJ, Lemons AR, Marshall NB, Goldsmith WT, Kashon ML, Anderson SE, Germolec DR, Beezhold DH
  2. Mold exposures promote both allergic and inflammatory responses By Kelly Lenox

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